Stress: The roots of resilience

Most people bounce back from trauma — but some never recover. Scientists are trying to work out what underlies the difference.

Virginia Hughes

10 October 2012

From http://www.nature.com/news/

Elizabeth Ebaugh is finally comfortable visiting the bridge from which she was thrown 26 years ago.

On a chilly, January night in 1986, Elizabeth Ebaugh carried a bag of groceries across the quiet car park of a shopping plaza in the suburbs of Washington DC. She got into her car and tossed the bag onto the empty passenger seat. But as she tried to close the door, she found it blocked by a slight, unkempt man with a big knife. He forced her to slide over and took her place behind the wheel.

The man drove aimlessly along country roads, ranting about his girlfriend's infidelity and the time he had spent in jail. Ebaugh, a psychotherapist who was 30 years old at the time, used her training to try to calm the man and negotiate her freedom. But after several hours and a few stops, he took her to a motel, watched a pornographic film and raped her. Then he forced her back into the car.

She pleaded with him to let her go, and he said that he would. So when he stopped on a bridge at around 2 a.m. and told her to get out, she thought she was free. Then he motioned for her to jump. “That's the time where my system, I think, just lost it,” Ebaugh recalls. Succumbing to the terror and exhaustion of the night, she fainted.

Ebaugh awoke in freefall. The man had thrown her, limp and handcuffed, off the bridge four storeys above a river reservoir. When she hit the frigid water, she turned onto her back and started kicking. “At that point, there was no part of me that thought I wasn't going to make it,” she says.

Few people will experience psychological and physical abuse as terrible as the abuse Ebaugh endured that night. But extreme stress is not unusual. In the United States, an estimated 50–60% of people will experience a traumatic event at some point in their lives, whether through military combat, assault, a serious car accident or a natural disaster. Acute stress triggers an intense physiological response and cements an association in the brain's circuits between the event and fear. If this association lingers for more than a month, as it does for about 8% of trauma victims, it is considered to be post-traumatic stress disorder (PTSD). The three main criteria for diagnosis are recurring and frightening memories, avoidance of any potential triggers for such memories and a heightened state of arousal.

Ebaugh experienced these symptoms in the months after her attack and was diagnosed with PTSD. But with the help of friends, psychologists and spiritual practices, she recovered. After about five years, she no longer met the criteria for the disorder. She opened her own private practice, married and had a son.

About two-thirds of people diagnosed with PTSD eventually recover. “The vast majority of people actually do OK in the face of horrendous stresses and traumas,” says Robert Ursano, director of the Center for the Study of Traumatic Stress at the Uniformed Services University of the Health Sciences in Bethesda, Maryland. Ursano and other researchers want to know what underlies people's mental strength. “How does one understand the resilience of the human spirit?” he asks.

Since the 1970s, scientists have learned that several psychosocial factors — such as strong social networks, recalling and confronting fears and an optimistic outlook — help people to recover. But today, scientists in the field are searching for the biological factors involved. Some have found specific genetic variants in humans and in animals that influence an individual's odds of developing PTSD. Other groups are investigating how the body and brain change during the recovery process and why psychological interventions do not always work. The hope is that this research might lead to therapies that enhance resilience.

A natural response

Although no one can fully understand what was going on in Ebaugh's mind during her attack, scientists have some idea of what was happening to her body. As soon as Ebaugh saw her attacker and his knife, her brain's pituitary gland sent signals to her adrenal glands, atop the kidneys, to start pumping out the stress hormones adrenaline and cortisol. In turn, her pulse quickened, her blood pressure rose and beads of sweat formed on her skin. Her senses sharpened and her neural circuits formed strong memories, so that if she ever encountered this threat in the future, she would remember the fear and flee.

The repercussions were profound. For the first week after the abduction, “I felt like a newborn baby”, Ebaugh says, “like I had to be held, or at least be in the presence of somebody”. She shivered constantly, was easily startled and felt only fear. She could not go near the grocery store.

Nearly every trauma victim experiences PTSD symptoms to some degree. Many people who are diagnosed with the disorder go on to have severe depression, substance-abuse problems or suicidal thoughts. PTSD can take a horrific toll. Between 2005 and 2009, as a growing number of soldiers faced multiple deployments in Iraq and Afghanistan, suicide rates in the US Army and Marines nearly doubled.

Over the past two decades, researchers have used various kinds of imaging techniques to peer inside the brains of trauma victims. These studies report that in people with PTSD, two areas of the brain that are sensitive to stress shrink: the hippocampus, a deep region in the limbic system important for memory, and the anterior cingulate cortex (ACC), a part of the prefrontal cortex that is involved in reasoning and decision-making. Functional magnetic resonance imaging (fMRI), which tracks blood flow in the brain, has revealed that when people who have PTSD are reminded of the trauma, they tend to have an underactive prefrontal cortex and an overactive amygdala, another limbic brain region, which processes fear and emotion (see 'The signature of stress').

People who experience trauma but do not develop PTSD, on the other hand, show more activity in the prefrontal cortex. In August1, Kerry Ressler, a neuroscientist at Emory University in Atlanta, Georgia, and his colleagues showed that these resilient individuals have stronger physical connections between the ACC and the hippocampus. This suggests that resilience depends partly on communication between the reasoning circuitry in the cortex and the emotional circuitry of the limbic system. “It's as if [resilient people] can have a very healthy response to negative stimuli,” says Dennis Charney, a psychiatrist at the Mount Sinai School of Medicine in New York, who has conducted several brain-imaging studies of rape victims, soldiers and other trauma survivors.

Environmental protection

After her abduction, Ebaugh began seeing a psychotherapist and several alternative-medicine practitioners. But more than anything else, she attributes her resilience to being surrounded by caring people — beginning within minutes of her escape.

After Ebaugh crawled up the rocky riverbank, a truck driver picked her up, took her to a nearby convenience store and bought her a cup of hot tea. Police, when they arrived, were sympathetic and patient. The doctor at the hospital, she says, treated her like a daughter. A close friend took her in for a time. And her family offered reassurance and emotional support. “For the first month, I almost had to tell people to stop coming because I was so surrounded by friends and community,” she says.

Studies of many kinds of trauma have shown that social support is a strong buffer against PTSD and other psychological problems. James Coan, a psychologist at the University of Virginia in Charlottesville, has done a series of experiments in which women lie in an fMRI scanner and see 'threat cues' on a screen. They are told that between 4 and 10 seconds later, they may receive a small electric shock on the ankle. The cue triggers sensory arousal and activates brain regions associated with fear and anxiety, but when the women hold the hands of their husbands2 or friends3, these responses diminish.

Social interactions are complex and involve many brain circuits and chemicals; no one knows exactly why they provide relief. Being touched by someone is thought to stimulate the release of natural opioids, such as endorphins, in the brain. The ACC is packed with opioid receptors, suggesting that touch could influence its response to stress.

Other clues come from the hormone oxytocin, which courses through the brain during social interaction and has been shown to boost trust and reduce anxiety. In one imaging study4, participants viewed frightening images after receiving nasal sprays of either oxytocin or a placebo. Those who sniffed oxytocin showed reduced activation in the amygdala and weaker connections between the amygdala and the brainstem, which control some stress responses, such as heart rate. The oxytocin surge that comes from being around other people could, like endorphins, help to reduce the stress response.

Past social interactions may also affect how a person responds to trauma. Chronic neglect and abuse unquestionably lead to a host of psychological problems and a greater risk of PTSD. Ressler, however, points to a factor that is well recognized but poorly understood: 'stress inoculation'. Researchers have found that rodents5 and monkeys6, at least, are more resilient later in life if they experience isolated stress events, such as a shock or a brief separation from their mothers, early in infancy.

Ebaugh says that early stress — and the confidence she gained in conquering it — helped her to recover from her traumatic abduction. She was born with a condition that made her feet turn inwards. At age ten, she underwent surgery to rebuild her knees followed by a year of intensive rehabilitation. “It wasn't foreign to me to be hurt and have to walk the walk of being strong again,” she says. “It's like a muscle, I think, that gets built up.”

Resilient by nature

Although most people, like Ebaugh, recover from trauma, some never do. Some scientists are seeking explanations for such differences in the epigenome, the chemical modifications that help to switch genes on and off (see page 171). Others are looking in the genes themselves. Take, for example, FKBP5, a gene involved in hormonal feedback loops in the brain that drive the stress response. In 2008, Ressler and his colleagues showed that in low-income, inner-city residents who had been physically or sexually abused as children, certain variants in FKBP5 predisposed them to developing PTSD symptoms in adulthood. Other variants offered protection7.

The most talked-about biological marker of resilience is neuropeptide Y (NPY), a hormone released in the brain during stress. Unlike the stress hormones that put the body on high alert in response to trauma, NPY acts at receptors in several parts of the brain — including the amygdala, prefrontal cortex, hippocampus and brainstem — to help shut off the alarm. “In resiliency, these brake systems are turning out to be the most relevant,” says Renu Sah, a neuroscientist at the University of Cincinnati in Ohio.

Interest in NPY and resilience took off in 2000, partly because of a study of healthy US Army soldiers who participated in a survival course designed to simulate the conditions endured by prisoners of war, such as food and sleep deprivation, isolation and intense interrogations8. NPY levels went up in the soldiers' blood within hours of the interrogations. Special Forces soldiers who had trained to be resilient had significantly higher NPY levels than typical soldiers.

Researchers are now conducting animal experiments to study how NPY works. In one experiment, a team at the Indiana University School of Medicine in Indianapolis restrained a rat in a tight-fitting plastic pouch for 30 minutes, then released it into a box with another rat9. The restraint made the rat so anxious that it avoided interacting with the other animal for 90 minutes. But when rats were injected with NPY before the treatment, they interacted with cage-mates as if nothing had happened.

The work could lead to treatments. Charney's group at Mount Sinai is carrying out a phase II clinical trial of an NPY nasal spray for individuals with PTSD. Others are investigating small molecules that can cross the blood–brain barrier and block certain receptors that control NPY release.

Conflict resolution

The US military is leading the hunt for additional biological markers of resilience. Since 2008 — driven in part by soaring suicide rates among soldiers — the US Army has collaborated with the National Institute of Mental Health and several academic institutions on a US$65-million project called Army STARRS (the Study to Assess Risk and Resilience in Servicemembers). The project has many parts, including a retrospective look at de-identified medical and administrative records for 1.6 million soldiers, in search of early warnings of suicide, PTSD and other mental-health problems. STARRS scientists are also collecting data — such as blood samples, medical histories and cognitive testing results — on tens of thousands of current soldiers. The researchers expect to publish their first findings early next year.

The military also funds research into animal models of resilience. Most rodents will quickly learn to associate painful foot shocks with a certain cue, such as a tone or a specific cage. After they have learned the association, the rodents freeze on experiencing the cue, even without the shock. Several years ago, Abraham Palmer, a geneticist now at the University of Chicago in Illinois, made a line of resilient mice by selectively breeding mice that froze for abnormally short periods of time. After about four generations, he had mice that froze for about half the time of typical animals10. The effect was not due to a difference in pain sensitivity or general learning ability. This month, Luke Johnson, a neuroscientist at the Uniformed Services University, will present data at the Society for Neuroscience meeting in New Orleans, Louisiana, showing that these mice have uncommonly low activity in the amygdala and hippocampus, consistent with human studies of PTSD resilience. They also have low levels of corticosterone, a stress hormone, in their urine.

“They have a quieter system, even at rest,” says Johnson. “It suggests that there are underlying biological traits that are associated with the capacity of the animal for fear memory.” In future experiments, Johnson plans to use the mice to study NPY and potential new therapies.

Ebaugh, who now specializes in therapy for trauma victims, agrees that drug-based treatments could aid in recovery. But some people may find relief elsewhere. Religious practices — especially those that emphasize altruism, community and having a purpose in life — have been found to help trauma victims to overcome PTSD. Ebaugh says that yoga, meditation, natural remedies and acupuncture worked for her.

Today, she buys groceries at the plaza where she was abducted, and she drives over the bridge she was thrown from as though it were any other road. She says that she has forgiven the man who abducted her. When she reflects on what he did, it's not with anger, sadness or fear. “It doesn't feel like it affects my life at all at this point, at least not in a negative way,” she says. “In a positive way, it's been a huge teacher.”

Virginia Hughes

10 October 2012

From http://www.nature.com/news/

Happier People Deal Better with Hardships

Philip Moeller
U.S. News & World Report
April 12, 2012
Article from Chicago Tribune

It's not avoiding problems that matters, but how we handle them

Some people are much more resilient than others. They bounce back quickly from a hard day. They mourn but adjust to even a calamitous setback, such as the death of a loved one or a natural disaster. The questions of why this is so and whether people can learn how to better deal with life's slings and arrows are easy to pose but hard to answer.

George Bonanno, a psychologist at Columbia University, has spent his career studying how people respond to adversity, particularly how they grieve over the death of a spouse or other loved one. "There's a lot to be learned from how well we cope with adversities," he says. "Human beings can cope pretty well with really bad things."

Bonanno says a couple of strong research trends are emerging that speak to why some people fare better than others. One of them is that it's not only OK to be happy when you're sad; it's therapeutic. Positive emotion, even the momentary experience of feeling joy or happiness, can be part of the coping and recovery process for people reeling from a traumatic event.

"People are able to experience joy and happiness even when the crappiest things are happening," he says. "It's a good thing to know that that's possible, or even permissible" when you're grieving or in emotional pain. "Laugh as much as you can."

A second concept Bonanno and others have researched is the notion that there is no single "best" way to respond to adversity. Those with great resilience adjust their responses, often unknowingly, to their specific situation. They exhibit great situational flexibility.

"We're finding that people who deal best with adversity are people who have flexible responses," he says. "They have multiple coping strategies, which is part of what we think of as mental health."

This flexibility may mean expressing emotion as part of a grieving and recovery process, or even as a way of confronting a difficult challenge. "We normally don't think of anger as being something good, but it can be a very helpful thing."

Flexibility can also mean suppressing emotion. This may be the best way to handle an immediate emergency or, to cite an extreme example, deal with a battlefield attack. Bonanno calls it "coping ugly." "Some situations are dire and you just have to get through them," he says.

It is not clear how or even whether people can train themselves to become more flexible in dealing with serious life events. Bonanno says there are three traits of resilient people:

1. They are able to "read" situations well and figure out an appropriate response.

2. They have a repertoire of various coping behaviors and can select one tailored to a specific situation.

3. They can shift gears, or recalibrate themselves, in response to the specifics of an adverse event or situation.

Roxane Cohen Silver, a psychologist at the University of California at Irvine, says not only is there no single way people respond to negative life events, but the same person may respond differently at different times in his or her life.

It also turns out that experiencing some adversity strengthens coping skills and can produce an "inoculation" effect. People who have not experienced serious problems in their lives may be emotionally devastated when bad things finally happen to them. Likewise, she says, people who have had too hard a time are not able to cope well, either.

"I met a woman years ago whose son had won every race he entered as a young boy," Silver says by way of illustration. "He was very gifted and just never lost at anything. When he was about 30, he had something bad happen to him, and he completely fell apart. His mother told me that she wished at some point that he had come in second in a race. She was basically saying that he had never learned to deal with adversity, and had not developed the requisite social and coping skills."

Maren Westphal worked on research that helped form the basis for Bonnano's conclusions about resilience and flexibility. She now is an assistant professor of psychology at Arcadia University. "There is one big message coming out" of the research, she says, "and it's that resilience is not about one factor or one dominant personal trait, but that many different variables contribute to resilience. The other piece about resilience is that it is a process, an outcome that unfolds over time."

While it is hard to predict which people will deal well with adversity, some variables have emerged, Westphal says. One negative factor is excessively dwelling on a problem or loss. "People who ruminate more do worse," she says. "They keep on thinking and processing about adverse things that happen to them." Women generally ruminate more on events than men.

Another negative factor is a person's degree of neuroticism. Viewing events negatively all the time makes it harder to respond to a serious adversity in a healthy, flexible manner.

On the positive side, Westphal says, people with a high sense of their own skills and self-worth tend to fare well. Whether or not you really are capable doesn't matter so much as that you think you are capable, she says. Having this sense of "feeling up to it" is very healthful. So is self-enhancement--inflating your own worth to deal with adversity. "People who perceive themselves in more flattering ways show better adjustments," Westphal says, even if their attitude turns off people in their social network.

Not surprisingly, the psychology of a flexible response to adversity is mirrored by research about how our brains deal with stress. In evolutionary terms, humans' response to adversity can be linked back to the basic survival instincts of our earliest ancestors. The most successful early humans tended to be the ones who recognized and responded quickly to physical threats. If they hadn't, of course, they would not have survived and passed on these traits to others. These responses triggered physical changes and also fired up parts of the brain that regulated the production of body chemicals related to stress.

Today's threats still include physical dangers, of course, but are more likely to center on emotional stresses. The brain still perceives adverse events as a threat, however, and springs into action. Up to a point, this is a good thing, notes Richard Davidson, a brain researcher at the University of Wisconsin. However, some people's brains respond too well or for too extended a period of time.

"This can lead to deleterious consequences," says Davidson, who is also a professor of psychology and psychiatry. "It can lead to the production of stress hormones that exceed what is required to deal with a stressful situation." In his research using brain scans, Davidson has shown that resilient people's brains are particularly effective at regulating these types of "fight or flight" reflexes. It's their brain's flexibility that drives their behavioral flexibility.

The bottom line: Everyone suffers losses and serious reversals during their lives. Trying to avoid them would not be an effective strategy even if that was possible. Instead, the research suggests we should recognize that bad things are part of life. Experts recommend trying to learn from past problems without letting them overwhelm you. And as with so many other life events, a strong social network can offer an essential support system.

Article from Chicago Tribune

Rwanda: Resilience Vis-a-Vis Trauma

BY YVONNE KAYITESHONGA, 5 APRIL 2012

Article from All Africa

OPINION

How, after experiencing the threat of annihilation, can one not to be subjected to the death drive? The human race is universally recognised as vulnerable to living through extreme situations in a state of distress.

However in such situations, some people have not or will not develop significant psychological problems. Many people are resilient, which is defined as the ability to cope relatively well with adversity.

The individual's amazing ability to cope with adversity is based on a fascinating complexity of genetic, developmental and environmental factors.

Keza, a female survivor of the Genocide against the Tutsi in Rwanda confirms this hypothesis. I met her in 2002 and she gave me her testimony. She overcame the confrontation with "the reality of death", as we shall see. Her name is Keza. She was aged 24 when she told me her story.

Keza is part of the category of individuals who have the ability to stay healthy though they have experienced events usually known to cause mental or somatic disorders. Until April 1994, Keza led a happy childhood in an ordinary family from the South of Rwanda and was the youngest in a family of four children, two girls and two boys. Her mother was a nurse and her father was a teacher. The memories of that time are perhaps not all positive but Keza remembers them with a touch of enchantment and nostalgia.

When the Genocide began, Keza's family fled the killers in a state of panic and became dispersed. Keza is offered shelter by a neighboring family who agrees to hide her. She's 19 years old; she spends her days in the ceiling where meals are served to her in secret by her hosts. But she listens every night to reports of macabre exploits, of killings and torture inflicting on other Tutsi from the village. Some are her neighbours; others are friends or friends of her parents. She says she spent three months with the certainty that she might pass away at any time. She had a fear of death, "that word could not express," she said. It was not only her life which was in danger. She was also very afraid for her family, which she knew would not be the same when the Genocide eventually stopped.

The Genocide was over and she found her mother, sister and brother. She heard from her brother that their eldest brother was killed savagely, when he had come out of hiding. Her brother had also witnessed the scene which was beyond imagination in its horror. Of their father, who was killed, his feet hanging from a truck body and his head dragging on the ground. Keza said she suffered terribly upon hearing of the murder of her brother and, the punishment imposed on her beloved father.

Her mother and her entire family were so affected by this situation that Keza was worried that everyone in the family would go crazy from the grief. This was, in fact, the case for her brother, who continues today to be under the care of the mental health services.

Keza has indeed suffered from what she had experienced during and after the Genocide. She said she decided after having almost experienced death, her only concern was "how can I live my life fully? How can I help my family to continue living? ".

One can see this directly in Keza, in the activities she undertook after the Genocide, and in her manner of speaking of herself and discussing her history.

She returned to school the year that followed the events, she finished high school, pursued graduate studies and graduated as a medical laboratory technician in 2000. She engaged herself in the cause of Genocide survivors and other vulnerable groups, studied social work and then began offering care as a trauma counselor and providing psychosocial care for women living with HIV. She is the bread winner for her family. In 2005, she met the love of her life and they were married the same year. In 2006, she gave birth to a daughter.

Keza builds on the love of her beloved late father had for her. Indeed, this young woman tells me with an insight and an emotional equilibrium that I have rarely seen in adolescents who survived the Genocide, with the following words: "My father loved me very much, he was intelligent and honest, and I am as intelligent as him. I have to keep the legacy he left with me by behaving with dignity especially vis-à-vis men".

This memory of a loving and intelligent father, the personal psychological resources of Keza, her sense of altruism, the resources of her family and professional environment, all these became real life examples of resilience that make Keza live her life today.

The author is the Director of Mental Health at the Rwanda Biomedical Centre.

Article from All Africa